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KMID : 0370220150590020066
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Yakhak Hoeji
2015 Volume.59 No. 2 p.66 ~ p.69
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Concise Synthesis of Flurbiprofen via Palladium-Catalyzed Cross-Coupling Reactions
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Han Young-Taek
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Abstract
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A concise synthesis of flurbiprofen, a member of the non-steroidal anti-inflammatory 2-arylpropionic acids, has been accomplished. The key feature of this synthesis involves successive palladium-catalyzed cross coupling reactions. In particular, a 2-arylacylate intermediate, which easily converted to the key 2-arylpropionic acid scaffold, was afforded by a versatile palladium-catalyzed cross coupling reaction between diazopropanate and bisphenylboronic acid. This synthetic procedure would facilitate synthesis of the flurbiprofen and anti-inflammatory 2-arylpropionic acid derivatives.
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KEYWORD
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flurbiprofen, synthesis, 2-arylpropionic acid, palladium catalyzed cross-coupling, diazo compound
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